持续静脉输注盖诺联合顺铂治疗晚期乳腺癌疗效及毒性观察

Clinical observation of gainuo administered by continuous infusion with cisplation for advanced breast cancer

摘要: 评价持续静脉输注盖诺联合顺铂方案治疗晚期乳腺癌的疗效及毒性反应。方法　盖诺6mg .(m2 .d) - 1静脉注射 15min, 第 1d, 接着, 盖诺 6mg .(m2 .d) - 1持续静脉输注 2 4h, 第 1～ 5d ;顺铂 4 0mg .d- 1静脉滴注 2h, 第 1～ 3d。结果　 36例晚期乳腺癌 (均为复治病例 ), 完全缓解 (CR) 2例, 部分缓解 14例, 总有效率 4 4.4 %。疗效与肿瘤转移部位及转移器官数目之间无明显相关性。毒性反应主要表现为骨髓抑制及脱发。结论　持续静脉输注盖诺联合顺铂方案治疗晚期乳腺癌疗效较好, 毒性反应能够耐受, 值得临床进一步使用。

Abstract: Objective This clinical trail is to evaluate the response and side effect of Gainuo administered by continuous infusion with Cisplatin for advanced breast cancer. Methods Gainuo 6mg.(m 2 .d) -1 bolus in 15-minute i.v. infusion,followed by 6mg.(m 2 .d) -1, in 24-hour i.v. infusion(Days 1～5). Cisplation 40mg.d -1, in 2-hour i.v. infusion(Days 1～3).The regimen was repeated every 21 days. Results The completed response were 2 cases, and the partial response 14 cases,The total respon...