宫颈癌组织中p15基因表达及其生物学意义

Expression of p15 Protein in the Patients of Cervix Carcinoma

摘要: 目的　探索p15基因与宫颈癌的关系。方法　应用免疫组化ABC方法对36例宫颈癌组织中p15基因表达产物进行检测。结果　p15基因产物的阳性表达率为55.6%(20/36)，其表达率与宫颈癌病理类型无显著关系，但与宫颈癌的浸润、转移及病人的生存期显著相关(P<0.05)。结论　p15基因表达产物可以作为判断宫颈癌预后的指标。

Abstract: Objective In order to investigate the prognostic value of p15 protein in the prediction for patient with cervix carcinoma.We examined the expression of p15 protein in 36 case of cervix carcinoma by immunohisto-chemical staining.Result p15 protein positive rate was 55.6%(20/36),the expression of p15 protein did not correlate with pathological pattern (P<0.05)，but it correlated with neoplasm invade and with lymphnode metastasis and with survival period of patient (P<0.05). Conclusion p15 protein expression may be a promising predictor for the prognosis of patient with cervix carcinoma.