对介入性热疗安全温度的实验研究

Experimental Study of Safe Tempera ture of Interventional Thermotherapy

摘要: 目的　研究 6 0℃的灌注液经肝动脉行灌注性热疗后, 肝脏活检及肝功各项指标的变化情况, 为临床灌注性热化疗提供安全数据。方法　经犬肝动脉灌注入 6 0℃生理盐水 2 0 0 ml,30分钟灌完。比较灌注前后肝脏穿刺活检及肝功的动态变化情况。结果　谷丙、谷草转氨酶于灌注后开始升高, 之后逐渐恢复, 一周后全部恢复正常, 而胆红素、白蛋白、γ- GT则无明显变化。肝脏活检也呈可逆性变化。结论　经肝动脉 6 0℃灌注液介入性热疗对肝脏损伤轻微, 临床应用此温度下的灌注性热化疗是安全的。

Abstract: Objective To evaluate the injury of interventional thermotherapy on Liver tissue at 60℃ throngh hepatic artery. Methods 200ml saline at 60℃ was perfused through hepatic artery in 30 minutes .Liver function and the biopsy of liver tissue were checked before and after perfusion . Results ALT, AST became abnormal after perfusion but recovered in a week, while BIL, ALB, γ GT indicated no significant changes at all. The biopsy of liver tissue also showed reversible changes. Conclusion Interventional thermotherapy ...