血清中sIL-2R和CA19-9水平对消化道癌的诊断价值

doi:10.3971/j.issn.1000-8578.2060

血清中sIL-2R和CA19-9水平对消化道癌的诊断价值

Diagnostic Value of Combined Determination of Serum sIL-2R and CA19-9 in Gastrointestinal Cancers

摘要

摘要: 目的　研究血清中sIL-2R及CA19-9联合检测对消化道癌的诊断价值。方法　研究分别采用ELISA法和RIA法对50例胃癌患者(包括术前或术后发生转移患者共30例)、30例胃良性疾病者、30例健康人的血清sIL-2R和CA19-9水平进行检测。结果　胃癌患者术前的血清sIL-2R、CA19-9水平明显高于胃良性疾病者及健康对照组，而术后水平下降与后两组比较无明显差异，胃癌一旦发生转移无论是发生在术前还是术后其血清sIL-2R及CA19-9水平均明显高于无转移的术前胃癌患者(P<0.01)，血清sIL-2R检测胃癌的敏感性为67.8%、特异性为77.8%，CA19-9的敏感性为83.3%、特异性83.3%，联合检测的敏感性为69.8%、特异性为93.7%。结论　测定血清sIL-2R、CA19-9水平对胃癌的早期诊断及监测转移复发有一定参考价值，联合检测此2项指标有助于筛选和确定胃癌患者，但由于敏感性较低使其临床应用范围受到限制。

Abstract: Objective To evaluate the diagnostic value of sIL-2R and CA19-9 combinated in serum of gastrointestinal cancer patients. Methods In this study we used the methods of ELISA and RIA to test the serum sIL-2R and CA19-9 of 110 cases which including 50 cases of cancer,30 cases of gastro benign disease and 30 cases of healthy controls. Results The serum levels of sIL-2R, CA19-9 of pre-operation patients of gastrocancer are significant higher than that of gastro benign disease and the controls.But there is no significant difference between the postoperations patients and the others.When the Metastasis is occurred,the serum level of sIL-2R and CA19-9 either pre-opration of post-opration are much higher than that of pre-opration patients without metastasis(P<0.01).The sensitivity of serum sIL-2R is 67.8%.The specificity is 83.3%.When the two methods combined,the sensitivity is 69.8%,and the specificity is 93.7%. Conclusion The methods detecting serum level of sIL-2R and CA19-9 are valuable for diagnoses and the observation of metastasis and occurrence.When the two methods are combined,they are helpful to select and diagnose gastrocancer.But the low sensitivity makes it district to clinical value.

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