EP和CAP方案治疗老年人中晚期非小细胞肺癌的临床疗效观察

A Comparison of the Therapeutic Effects of EP and CAP Regimen for Treatment of Advanced Non-small Cell Lung Cancer of Older Patient

摘要: 目的　比较EP方案(Vp-16胶囊，DDP)与CAP方案(CTX、ADM与DDP)治疗非小细胞肺癌的疗效。方法　60例晚期非小细胞肺癌随机分成两组、各30例。结果　EP组有效率为38.8%、CAP组为33.3%，两组间疗效无显著性差异(P>0.05)。CAP组消化系统毒性作用及脱发反应较EP组严重、造血系统毒性反应相似。结论　两方案可作为老年人非小细胞肺癌一线方案，DDP、Vp-16胶囊方案易行、毒副反应小、耐受性好。

Abstract: Objective To evaluate the curative effects of EP (oral Vp-16 capsule+DDP)regimen and CAP(CTX+ADM+DDP)regimen on non-small cell lung Cancer of older patient. Methods 60 cases of advanced non-small cell lung cancer were randomly divided into two groups.Each group has 30 cases. Results Response rates of EP regimen and CAP regimen were 38.8% and 33.3% respectively.There was no statistical significant difference between them (P>0.05).Gastrointestinal tract reaction and epilation reaction of CAP regimen were more serious than that of EP regimen(P<0.05).Mylos-suppression had no statistical difference between two regimens. Conclusion Both EP regimen an CAP regimen can be used as first line regimens for treatment of non-small cell lung cancer of older patient.The EP regimen is regarded as a better,convenient and tolerable regimen.