吉粒芬治疗化疗所致粒细胞减少的临床研究

Clinical study of low dose and short term rhG-CSF on neutropenia induced by chemotherapy

摘要: 目的　研究低剂量、短期使用吉粒芬治疗化疗所致粒细胞减少的临床疗效。方法　108例患者随机分A、B、C3组。A组吉粒芬75μg/qd×3d；B组吉粒芬75μg/qod×6d；C组吉粒芬75μg/qd×5d。均为皮下注射。结果　低剂量、短期使用吉粒芬在粒细胞降至1500×109/L以上时有效，副作用少，能使患者安然度过粒细胞下降易感染期，以B组隔日使用疗效最好。结论　低剂量、短期使用吉粒芬可在粒细胞未降至1500×109/L以上时使用有效，量不变隔日用效果更好。

Abstract: Objective To Study the effect of low dose and rh-GCSF(Recombinant　Human Granulocyte Colony Stimulating Factor) on leukepenia and nenutropenia induced by chemotherapy in a randomized clinical trial. Methods The total patients entrolled were 108 in number and were randominzed into A B and C group(36patients each).In group A rhG-CSF was given for 3 day at the dose of 75μg/dS.C. In group B rh-GCSF was given for 6 days at the dose of 75μg/d S.C In group C rhG-CSF was given for 5 day at the dose of 75μg/d S.C. Results Iow dose and short term rhG-CSF remarkably increased the count of WBC and ANC and lowored the number of days with WBC<4.0×109/l,ANC<50% by cancer chemotherapy with minimal side-effects.In group B is was higher than A.C group for the effect. Conclusion Low dose and short term rhG-CSF were effective,B group had the hest effect.