PTEN、p27~(kip1)、VEGF在子宫内膜癌中的表达及意义
The expression and significance of PTEN、p27~(kip1) and VEGF in endometrial carcinoma
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摘要: 目的 探讨抑癌基因PTEN、p2 7kip1、VEGF在子宫内膜癌中的表达、意义及三者之间的相关性。方法 采用免疫组化SP法检测 32例子宫内膜腺癌, 13例子宫内膜不典型增生和 10例正常子宫内膜石蜡切片中PTEN、p2 7kip1及VEGF的表达。结果 子宫内膜腺癌组织与子宫内膜不典型增生、正常子宫内膜组织比较, PTEN、p2 7kip1阳性表达率明显降低, 差异有非常显著性 (χ2 =11.0 9,χ2 =9.4 6 6, P <0 .0 1), VEGF表达率明显增加, 差异有非常显著性 (χ2 =2 1.2 5 3,P <0 .0 1)。PTEN表达与肿瘤分化、肌层浸润程度、淋巴结转移有关 (P <0 .0 5 ), 与临床分期无关 (P >0 .0 5 )。在子宫内膜腺癌组织中, PTEN与p2 7kip1表达呈正相关 (r=0 .74 4, P <0 .0 1), 与VEGF表达呈负相关 (r =- 0 .738,P <0 .0 1)。结论 PTEN、p2 7kip1的失表达与VEGF的过表达在子宫内膜腺癌的发生发展中起着一定的作用, PTEN与 p2 7kip1、VEGF的异常表达密切相关 ...Abstract: Objective To study the expression and significance of PTEN?p27 kip1 ? and VEGF in endometrial carcinoma and its relationships. Methods Using immunohistochemistry test (sp methods), We examined the expression of PTEN?p27 kip1 and VEGF in 32 cases of endometrial carcinoma, 13 cases of uterus atypical hyperplasia endometrium and 10 cases of normal endometrium. Results In endometrial carcinoma tissues, the positive rates of PTEN?p27 kip1 were significantly lower than that of uterus atypical hyperpla...
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