雄激素/雄激素受体信号通路在肝细胞癌中的研究进展

Research Progress of Androgen/Androgen Receptor Signaling Pathway in Hepatocellular Carcinoma

摘要: 肝细胞癌是一种高死亡率的原发性肝癌。在我国，男性肝细胞癌发病率与女性发病率之比为2:1~5:1。男性和女性在性激素通路方面的差异和雄激素/雄激素受体与HBV相互作用均可导致肝细胞癌发生性别差异。雄激素/雄激素受体致癌通路在肝细胞癌中的研究受到较大关注。本综述主要总结近年来雄激素/雄激素受体在肝细胞癌发病性别差异中致癌作用机制及其研究进展。

Abstract: Hepatocellular carcinoma (HCC) is a kind of primary liver cancer with a high mortality rate. In China, the incidence ratio in males to females with HCC is 2:1–5:1. The difference in sex hormone pathways between males and females and the interaction between androgen/androgen receptors and HBV can lead to an incidence difference between males and females with HCC. Hence, the androgen/androgen receptor oncogenic pathway in hepatocellular carcinoma has received considerable attention. This review mainly summarizes the recent research progress on the androgen/androgen receptor oncogenic pathway in hepatocellular carcinoma.