多西紫杉醇联合5-氟尿嘧啶、亚叶酸钙及草酸铂治疗胃癌肝转移的临床观察
Clinical Observation of Taxotere in Combination with 5-Fluorouracil,Leucovorin and Oxaliplatin for Hepatic Metastasis of Gastric Cancer
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摘要: 目的 观察多西紫杉醇联合5-氟尿嘧啶、亚叶酸钙及草酸铂治疗胃癌肝转移的疗效及毒副反应。方法 多西紫杉醇50mg/m^2,d1,草酸铂100mg/m2,d1,5-Fu750mg/（m2.d）持续静脉滴注48h,d1～2,CF200mg,d1～3,每2周重复。完成3周期后评价疗效。结果 全组24例患者,治疗后CR2例,PR12例,RR（CR＋PR）为58.3%。中位生存时间（MST）11.2个月,中位疾病进展时间（TTP）6.6个月。主要不良反应为骨髓抑制、神经毒性、粘膜炎等。结论 多西紫杉醇联合5-氟尿嘧啶、亚叶酸钙及草酸铂治疗胃癌肝转移有效率较高,可提高患者的生存质量,毒副作用能耐受。Abstract: Objective To evaluate the effects and adverse reactions of taxotere in Combination with 5-Fluorouracil、Leucovorin and Oxaliplatin regimen for patients with a hepatic metastasis of Gastric Cancer. Methods Taxotere 50 mg/ m2 iv d1, continuous, 5-FU 750 mg/(m2·d) continuous infusion 48 h d1～2, CF 200 mg iv d1～3, Oxaliplatin 100 mg/m2d1, repeated every 2 weeks. Tumor assessment was done after 3 cycles. Results Among 24 patients, 2 patients reached complete response (CR), 12 partial responses (PR). The overall r...
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