癌因性疲劳动物模型的研究进展

Research Progress on Animal Model for Cancer-related Fatigue

摘要: 癌因性疲劳（CRF）是一种与癌症本身或癌症治疗相关的常见症状，它不仅会中断患者的治疗，还会严重影响患者生存质量。目前，CRF具体的机制仍不明确，且缺乏公认的有效治疗。建立规范的相关动物模型并进一步探讨CRF的产生机制是找寻有效治疗途径的前提条件。本文综述国内外CRF的动物模型，以期找寻合适的临床前实验的造模方法，并区分不同干预效果的差异，从而为CRF动物的模型选择提供指导。

Abstract: Cancer-related fatigue (CRF) is a common symptom which associated with cancer itself or cancer treatments. CRF will not only interrupt the patient's treatment, but also affect the patient's quality of life seriously. To date, the pathogenesis of CRF is still unclear, and recognized effective treatment is lacking. It is the precondition of establishing standardized animal models for CRF to find effective treatments. This paper summarizes the animal model of CRF in order to find suitable methods, and distinguish the effects of different interventions.