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于盼, 朱丽华, 阙祖俊, 田建辉. 肺癌循环肿瘤细胞的研究进展[J]. 肿瘤防治研究, 2021, 48(5): 519-523. DOI: 10.3971/j.issn.1000-8578.2021.20.1073
引用本文: 于盼, 朱丽华, 阙祖俊, 田建辉. 肺癌循环肿瘤细胞的研究进展[J]. 肿瘤防治研究, 2021, 48(5): 519-523. DOI: 10.3971/j.issn.1000-8578.2021.20.1073
YU Pan, ZHU Lihua, QUE Zujun, TIAN Jianhui. Research Advances of Circulating Tumor Cells in Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2021, 48(5): 519-523. DOI: 10.3971/j.issn.1000-8578.2021.20.1073
Citation: YU Pan, ZHU Lihua, QUE Zujun, TIAN Jianhui. Research Advances of Circulating Tumor Cells in Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2021, 48(5): 519-523. DOI: 10.3971/j.issn.1000-8578.2021.20.1073

肺癌循环肿瘤细胞的研究进展

Research Advances of Circulating Tumor Cells in Lung Cancer

  • 摘要: 转移是导致肺癌患者死亡的主要因素,积极防治转移的发生是提高患者疗效的关键。循环肿瘤细胞(CTCs)是启动远处转移的重要环节,自原发灶脱落开始即触发一系列转移级联反应,最终在远处靶器官定植和增殖。近年来,肺癌CTCs的检测技术手段不断优化,不仅可以对CTCs进行计数,还可鉴定不同亚群。肺癌CTCs检测可用于早期筛查、手术及放化疗后的预后预测、免疫靶向治疗的疗效评价等方面,动态监测肿瘤异质性,有助于调整个体化治疗方案,达到精准治癌的目的。田建辉研究组建立世界首例人肺腺癌循环肿瘤细胞系,将其融入肺癌亚临床核心病机“正虚伏毒”学说的探索,并积极促进肺癌特异性研究平台的构建,以期提高肺癌转移的研究和防控效率。

     

    Abstract: Metastasis is the main factor leading to the death of patients with lung cancer, and active prevention is the key to improve the efficacy of treatment. Circulating tumor cells (CTCs) play an important role in initiating metastasis. They trigger a series of metastatic cascade reactions at the moment of shedding from the primary focus, and finally colonize and proliferate in the distant target organs. In recent years, the detection technology of lung cancer CTCs has been continuously optimized. It can not only count CTCs, but also identify different subsets. CTCs detection of lung cancer can be used for early screening, the prediction of prognosis after surgery and chemoradiotherapy and the evaluation of curative effect of targeted immunotherapy. Dynamic monitoring of tumor heterogeneity is helpful to adjust personalized treatment plan and achieve the accurate treatment of cancer. Tian Jianhui's research group established the world's first circulating tumor cell line of human lung adenocarcinoma, integrated it into the theory of "positive deficiency and toxin" in the subclinical core pathogenesis of lung cancer, and actively promoted the construction of a specific research platform for lung cancer, in order to improve the research, prevention and control efficiency of lung cancer metastasis.

     

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