原发星形细胞瘤中TP53、PDGF、EGFR的表达及与临床病理特征和预后的相关性

孙晓玲; 张晓娟; 张清泉; 邱雷; 王林娜; 侯素平

doi:10.3971/j.issn.1000-8578.2021.20.0818

原发星形细胞瘤中TP53、PDGF、EGFR的表达及与临床病理特征和预后的相关性

Expressions of TP53, PDGF and EGFR in Primary Astrocytomas and Their Correlation with Clinicopathological Features and Prognosis

摘要

摘要:
目的探讨TP53、PDGF、EGFR在原发星形细胞瘤中的表达，分析其与临床病理特征和预后的相关性。
方法回顾性收集90例原发星形细胞瘤患者临床病理资料，采用免疫组织化学检测原发星形细胞瘤组织样本中TP53、PDGF、EGFR表达，随访患者生存情况，Cox回归分析影响预后的因素。
结果 TP53表达于细胞核，PDGF、EGFR表达于细胞质和细胞膜，TP53、PDGF、EGFR在星形细胞瘤组织中阳性率分别58.89%、51.11%、48.89%，显著高于正常脑组织，差异有统计学意义（均P < 0.05）；肿瘤大小≥3 cm患者TP53阳性表达率高于肿瘤大小 < 3 cm患者，WHO分期Ⅲ~Ⅳ期患者TP53、PDGF、EGFR阳性表达率高于Ⅰ~Ⅱ期患者，差异均有统计学意义（均P < 0.05）；TP53、PDGF、EGFR阳性表达患者的生存期均短于阴性表达患者（均P < 0.05）。Cox回归分析发现，WHO分期、TP53、PDGF、EGFR均是原发星形细胞瘤预后的影响因素。
结论 TP53、PDGF、EGFR在原发星形细胞瘤中高表达，且与肿瘤进展密切相关，是影响患者预后的因素。

Abstract:
Objective To investigate the expression of TP53, PDGF and EGFR in primary astrocytomas, and analyze their correlation with clinicopathological features and prognosis.
Methods We analyzed retrospectively the clinicopathological data of 90 patients with primary astrocytoma. The expressions of TP53, PDGF and EGFR in primary astrocytoma tissue samples were detected by immunohistochemistry. The survival of patients was followed up and Cox regression analysis was used to determine the prognostic factors.
Results TP53 was expressed in the nucleus, PDGF and EGFR were expressed in the cytoplasm and cell membrane. The positive expression rates of TP53, PDGF and EGFR were 58.89%, 51.11% and 48.89%, significantly higher than those in normal brain tissues (all P < 0.05); the positive expression rate of TP53 in patients with tumor size ≥3 cm was higher than that in patients with tumor size < 3 cm. The positive expression rates of TP53, PDGF and EGFR in patients with WHO stages Ⅲ-Ⅳ were higher than those in patients with WHO stageⅠ-Ⅱ(all P < 0.05); the survival time of patients with positive expression of TP53, PDGF and EGFR were shorter than those of negative expression (all P < 0.05). Cox regression analysis found that WHO staging, TP53, PDGF and EGFR were all factors influencing the prognosis of primary astrocytomas patients.
Conclusion TP53, PDGF and EGFR are highly expressed in primary astrocytomas and closely related to tumor progression. They are factors that affect the prognosis of patients.

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