Abstract: The spread of COVID-19 has affected the routine medical care of cancer patients. Due to the low immunity, tumor patients are vulnerable to infection and the prognosis is poor. Especially the patients undergoing radiotherapy need to travel between the ward and the radiotherapy room every day, which increases the chance of infection and they should be the focus of epidemic prevention object. As an oncology hospital, our hospital achieved prevention, control and admission during the outbreak. Under the guidance of infection and control office of the hospital, hospital-level and department-level prevention and control teams were established to adopt a series of prevention and control management measures, including the combination of online training and offline assessment, the establishment of a unified and standardized space division for the seven wards of the radiotherapy center, standardization of patient admission, semi-enclosed management of wards, optimization of radiotherapy process and closed-loop management. In Wuhan, where the epidemic outbreak was the most severe in China, the radiotherapy center of our hospital achieved zero infection of patients and staff within two months of clinical reception, effectively prevented new coronary pneumonia, and ensured the safety and normal treatment of the patients undergoing radiotherapy.