SLAMF7-SLAMF7信号通路在肿瘤进展中的作用及相关机制

Role and Mechanism of SLAMF7-SLAMF7 Signaling Pathway in Tumor Progression

摘要: 信号淋巴细胞激活分子成员7（SLAMF7）不仅表达于多种肿瘤细胞表面，也表达于众多免疫细胞中，如自然杀伤细胞、CD4⁺T细胞、CD8⁺T细胞、B细胞、树突状细胞、单核/巨噬细胞等，并参与调控肿瘤微环境中肿瘤细胞及免疫细胞的增殖、黏附、生长及分化，最终影响着免疫细胞的抗肿瘤作用。本文将对SLAMF7调控免疫细胞抑制肿瘤细胞功能的研究现状进行综述。

Abstract: The signaling lymphocytes activating molecule factor 7(SLAMF7) is not only expressed on the surface of some malignant tumor cells, but also widely expressed in immune cells, including natural killer cells, CD4⁺T cells, CD8⁺T cells, B cells, dendritic cells (DCs) and monocytes/macrophages. It can regulate the biological behavior of tumor cells as well as immune cells and contribute to anti-tumor effects of immune cells in tumor microenvironment. Herein, we review the functional role of SLAMF7 in regulating immune cells to suppress tumor progression.