Abstract: Bone metastasis is a common complication of malignant tumors. Breast cancer and lung cancer are mostly with osteolytic bone metastases. The clinical manifestations of bone metastasis are pain, hypercalcemia, pathological fractures, etc., seriously affecting the quality of life of patients and shorten the survival time. However, the mechanism of how tumor cells metastasize into bone microenvironment is not completely clear. The latest studies suggest that before the clinical symptoms of bone metastasis, there is a regulatory role between malignant tumor cell and bone microenvironment. In this paper, we review the specificity of tumor cells and bone microenvironment, and the mutual regulation between tumor cells and bone cells to guide clinical medication.