Objective To investigate the application of superb micro-vascular imaging(SMI) technology in accurately targeted biopsy of prostate cancer.

Methods One month after 87 patients with clinically suspected prostate cancer received the first systematic 12-points puncture, 48 patients received system 12-points puncture, 39 patients received SMI technology to accurately target abnormal areas replacing local system puncture. According to histo pathological confirmation of the first puncture, the results of two methods in prostate cancer biopsy were compared and analyzed.

Results There was no significant difference in prostate volumes between patients with malignant and benign prostate diseases, and the difference in serum PSA levels was statistically significant(t=2.045, P=0.04). In the SMI group, 20 cases were malignant, puncture positive rate was 51.28%, and the total numbers of puncture were 456 needle points; in the control group, 14 cases were malignant, puncture positive rate was 29.17%, and the total numbers of puncture were 576 needle points; there were significant differences in puncture positive rate and the average numbers of puncture point between the two groups (χ²=4.420, P=0.036; t=13.18, P=0.000). There were 79 cases of malignant pathological tissues and the highest Gleason scores were 7.2±0.4 in the SMI group; in the control group, there were 64 cases of malignant pathological tissues, and the highest Gleason scores were 6.5±0.4; there were significant differences between the two groups in the positive rate of single sampling and the highest Gleason score (χ²=8.232, P=0.004; t=5.940, P=0.000).

Conclusion SMI technology to guide prostate cancer biopsy could improve the positive rate of draw materials.