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李群秀, 付凤林, 张胜利. Integrinβ1和CARMA-3蛋白在膀胱癌组织中的表达与经尿道膀胱肿瘤电切术后复发的相关性[J]. 肿瘤防治研究, 2019, 46(3): 239-242. DOI: 10.3971/j.issn.1000-8578.2019.18.1182
引用本文: 李群秀, 付凤林, 张胜利. Integrinβ1和CARMA-3蛋白在膀胱癌组织中的表达与经尿道膀胱肿瘤电切术后复发的相关性[J]. 肿瘤防治研究, 2019, 46(3): 239-242. DOI: 10.3971/j.issn.1000-8578.2019.18.1182
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LI Qunxiu, FU Fenglin, ZHANG Shengli. Relationship of Integrinβ1 and CARMA-3 Protein Expressions with Recurrence of Bladder Cancer After Transurethral Resection of Bladder Tumor[J]. Cancer Research on Prevention and Treatment, 2019, 46(3): 239-242. DOI: 10.3971/j.issn.1000-8578.2019.18.1182
Citation: LI Qunxiu, FU Fenglin, ZHANG Shengli. Relationship of Integrinβ1 and CARMA-3 Protein Expressions with Recurrence of Bladder Cancer After Transurethral Resection of Bladder Tumor[J]. Cancer Research on Prevention and Treatment, 2019, 46(3): 239-242. DOI: 10.3971/j.issn.1000-8578.2019.18.1182
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Integrinβ1和CARMA-3蛋白在膀胱癌组织中的表达与经尿道膀胱肿瘤电切术后复发的相关性

Relationship of Integrinβ1 and CARMA-3 Protein Expressions with Recurrence of Bladder Cancer After Transurethral Resection of Bladder Tumor

    摘要
  • 摘要:
    目的 探讨膀胱癌组织中Integrinβ1和CARMA-3蛋白的表达及其与患者经尿道膀胱肿瘤电切术后复发的相关性。
    方法 选取160例经尿道膀胱肿瘤电切术治疗的膀胱癌患者，保留患者病理标本，并对患者随访5年，最终108例纳入研究。根据患者复发情况分为短期复发组和长期首次复发组。免疫组织化学法检测膀胱癌肿瘤组织中Integrinβ1和CARMA-3表达，并分析其表达与经尿道膀胱肿瘤电切术后复发的相关性。
    结果 短期复发组Integrinβ1和CARMA-3蛋白的表达显著高于长期首次复发组（P < 0.05）；Integrinβ1和CARMA-3蛋白的表达与T分期以及分级存在正相关（均P < 0.05）；CARMA-3和Integrinβ1蛋白在膀胱癌组织中的表达呈正相关（r=0.774, P < 0.05）。
    结论 CARMA-3和Integrinβ1蛋白是尿道膀胱肿瘤电切术后膀胱癌复发的风险因素。

     

    Abstract:
    Objective To investigate the relationship of Integrinβ1 and CARMA-3 expressions with the recurrence of bladder cancer after transurethral resection of bladder tumor(TURBT).
    Methods We collected 160 patients with bladder cancer treated with TURBT. Pathological specimens were retained and patients were followed up for 5 years. We included 108 cases in the study. According to the patients' recurrence, the patients were divided into the short-term recurrence group (50 patients with recurrence within 6 months) and the long-term first recurrence group (58 patients with the first recurrence over 3 years). The protein expressions of CARMA-3 and Integrinβ1 were analyzed by immunohistochemical staining. And, the relationship of Integrinβ1 and CARMA-3 protein expressions with the recurrence of bladder cancer was analyzed.
    Results The expressions of Integrinβ1 and CARMA-3 in short-term recurrence group were significantly higher than those in long-term first recurrence group (P < 0.05). And the expressions of Integrinβ1 and CARMA-3 were positively correlated with T stage and tumor differentiation (P < 0.05). Besides, Integrinβ1 and CARMA-3 expressions were positively correlated (r=0.774, P < 0.05).
    Conclusion CARMA-3 and Integrinβ1 proteins are risk factors for the recurrence of bladder cancer after TURBT.

     

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