Abstract: Among the death cause of cancer, the malignancies themselves were the top cause and the anti-cancer therapy-associated heart cardiovascular disease was the second one. Both cancer and cardiovascular disease are the common chronic non-communicable diseases. And various anti-cancer drugs would inevitably induce some cardiovascular events. These anti-cancer drugs include the traditional cytotoxic agents, molecularly targeted drugs and immunological checkpoint inhibitors. In this review, the possible pathogenesis of anti-cancer drug-induced cardiovascular diseases will be discussed, which will be useful for the cancer research and oncological clinical practice.