Abstract:
Objective To analyze PET/CT imaging manifestations of different pathological subtypes of retroperitoneal liposarcoma, to explore the application value of PET/CT in retroperitoneal liposarcoma.
Methods We included 48 patients diagnosed pathologically as retroperitoneal liposarcoma. According to the classification of WHO2013 soft tissue tumor and FNCCLE criterion, the patients were divided into three groups, G1 group included nine well-differentiated liposarcoma(WDLS), G2 group included seven myxoid liposarcoma (MLS), and G3 group included 29 dedifferentiated liposarcoma (DDLS), two pleomorphic liposarcoma(PLS), and one round cell liposarcoma(RCLS). PET/CT manifestations of different subtypes of retroperitoneal liposarcoma were analyzed. FDG metabolic degree and uniformity among three groups were compared by ANOVA test.
Results (1) WDLS showed fat density mass with septa and small nodules, with mild FDG uptake; MLS showed low density mass with mild to moderate FDG uptake, with or without fat; DDLS/PLS/RCLS showed soft tissue mass with high FDG uptake, with or without fat; (2)All lesions had local invasion, without lymph node metastasis; one recurrent DDLS had meditational metastasis; one RCLS had peritoneal metastasis; (3)The mean SUVmax G1 < G2 < G3 (2.6±1.6, 4.6±2.4, 9.8±9.3), there was significant difference between G1 and G3 groups(P < 0.05).
Conclusion Different subtypes of retroperitoneal liposarcoma have different PET/CT manifestations. Preoperative PET/CT could accurately show the extent and metastasis of tumor and predict the pathological subtype, which could help the design of surgical scheme.
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