Abstract: Sentinel node (SN) detection and biopsy are important for timely diagnosis and treatment of cancer. Endoscopic submucosal dissection technique is clinically used to treat early gastric cancer, but there is not accurate intuitive judgment of lymph metastasis so as to increase the risk of missing the timing of treatment. Malignant gastric tumor contains lymphatic basin with the sentinel lymph node. Sentinel lymph node can be obtained to guide the surgery by lymphatic basin dissection. So, laparoscopic local gastrectomy combined with lymphatic basin dissection is a recommendable operation, and it can not only achieve the therapeutic effect of endoscopic submucosal dissection but also avoid the risk of lymph node micrometastasis. In this paper, the related difficulties and problems of this technology are summarized for clinical reference.