抑酸药物对小分子靶向药物吸收的影响

Effect of Antiacid Drugs on Absorption of Small Molecular Targeted Drugs

摘要: 胃液pH（potential hydrogen）是影响小分子靶向药物（small molecular targeted drugs, SMTD）在体内溶解的一个重要因素，而抑酸药物（antiacid drugs, AD）可通过改变胃内pH来影响一部分SMTD的溶解度，药物溶解度高，则药物吸收较好，反之若溶解度低，则药物吸收较差。为探讨AD对SMTD体内吸收的作用关系，该文对相关文献进行检索并整理。通过整理可知，达沙替尼、厄洛替尼、吉非替尼、拉帕替尼和尼洛替尼受到AD的影响较为显著，提示临床应重视AD对SMTD吸收的影响，以避免降低SMTD的吸收和疗效。

Abstract: Gastric juice pH is an important factor affecting the dissolution of small molecular targeted drugs (SMTD) in vivo, and the antiacid drugs (AD) can affect the solubility of SMTD by altering pH in the stomach. When the solubility is high, the absorption of the medicine is better; otherwise, if the solubility is low, the absorption of the medicine is poor. In order to investigate the effect of AD on the absorption of SMTD, electronic database were searched for the related articles. According to the related articles, it can see that dasatinib, erlotinib, gefitinib, lapatinib and nilotinib are significantly affected, which indicated that attention should be paid to the effect of AD on the absorption of SMTD, to avoid reducing the bioavailability and efficacy of SMTD.