血清碱性磷酸酶及乳酸脱氢酶与Ⅰ~Ⅲ期乳腺癌患者生存的相关性

何明媛; 李凤虎; 常建英; 李杰慧; 王鹤然; 宋阳; 刘丽阳; 冉立

doi:10.3971/j.issn.1000-8578.2017.17.0544

血清碱性磷酸酶及乳酸脱氢酶与Ⅰ~Ⅲ期乳腺癌患者生存的相关性

Correlation of Serum Alkaline Phosphatase and Lactate Dehydrogenase with Survival of Stage Ⅰ-Ⅲ Breast Cancer Patients

摘要

摘要:
目的本文旨在分析Ⅰ~Ⅲ期乳腺癌患者治疗前后血清碱性磷酸酶（ALP）及血清乳酸脱氢酶（LDH）水平对其预后的影响。
方法本研究收集了贵州省肿瘤医院肿瘤科2003—2012年治疗有完整资料的467例Ⅰ~Ⅲ期女性乳腺癌患者，中位随访时间61月。回顾性分析患者新辅助/辅助治疗前、治疗后1周内的血清ALP、LDH水平与患者复发转移率、PFS及OS的关系。
结果 Ⅰ~Ⅲ期乳腺癌患者治疗后ALP水平升高组较未升高组OS及PFS缩短（P＜0.05）；治疗后LDH水平升高组较未升高组PFS缩短（P＜0.05），治疗后LDH水平升高组较未升高组复发转移率升高（P＜0.05）。
结论治疗后ALP、LDH水平可作为Ⅰ~Ⅲ期乳腺癌患者OS及PFS的预后因素，且治疗后LDH水平对复发转移有一定参考意义。

Abstract:
Objective To evaluate the prognostic value of serum alkaline phosphatase (ALP) and serum lactate dehydrogenase (LDH) levels in stage Ⅰ-Ⅲ breast cancer patients before and after treatment.
Methods A clinical retrospective analysis was performed with complete data from 476 stage Ⅰ-Ⅲ breast cancer patients who received treatment in the Department of Oncology of Guizhou Cancer Hospital from 2003 to 2012. The median follow-up time was 61 months. Patients' serum levels of ALP and LDH were detected before and within one week after treatment and then their relationship with recurrence and metastasis rates, PFS and OS were analyzed.
Results For stageⅠ-Ⅲ breast cancer patients, OS and PFS in the high ALP level group after treatment were significantly shorter than those in the low ALP level group(P < 0.05). The PFS in the high LDH level group after treatment was significantly shorter than that in the low LDH level group (P < 0.05). The relapse/metastasis rate in the high LDH level group after treatment was significantly higher than that in the low LDH level group(P < 0.05).
Conclusion ALP and LDH levels after treatment could be used as the prognostic factors for OS and PFS of stage Ⅰ-Ⅲ breast cancer patients. LDH level after treatment could provide some reference for recurrence and metastasis.

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