活性肽调节肿瘤细胞代谢途径的研究进展

Research Progress of Active Peptides Regulating Tumor Cells Metabolic Pathways

摘要: 生物活性肽具有多种生物学功能，可特异性作用于恶性肿瘤，与其生长转移相关的信号转导分子相互作用，抑制肿瘤生长或促进肿瘤细胞凋亡。本文从活性肽对STAT3信号通路的调节、对TRAIL死亡受体信号通路的调控、PKM2调节有氧糖酵解以及对NF-кB信号通路的调控来抑制肿瘤细胞生长代谢等几个方面进行概述，为寻找更明确更具有针对性的抗肿瘤活性肽类药物提供参考。

Abstract: Bioactive peptides have a variety of biological functions. They can influence malignant tumor specifically, interact with signal transduction molecule aboutgrowth and metastasis, and inhibit the growth of tumourcells or accelerate the apoptosis. In order to provide a reference for researching the more purposeful anti-tumor bioactive peptides, this paper will overview the research progress of active peptides regulating tumor cells metabolic pathways from STAT3 signalpathway, TRAIL death receptor pathway, PKM2aerobic glycoysisand NF-кB signalpathway.