Abstract: Solute carrier family 3 member 2 (SLC3A2) is a member of type Ⅱ transmembrane glycoprotein of the SLC3 family and a component of heteromericamino acid transports (HATs). While widely expressed in cells, HATs mediate the transmembrane transport of all essential amino acids and maintain the intracellular stability of amino acid concentrations, which is important to the normal function of cells. Researches show that SLC3A2 is highly expressed in various tumor cells and involved in the malignant transformation of cells.However, the mechanisms are still lacking. In this review, we will discuss the advances in the structure and function of SLC3A2 and its mechanism in tumor occurrence and development.