饮茶与牙龈癌发病关系的病例对照研究

刘凤琼; 鄢灵君; 陈法; 黄江峰; 刘芳萍; 邱宇; 林李嵩; 郑晓燕; 伍俊锋; 何保昌

doi:10.3971/j.issn.1000-8578.2017.02.012

饮茶与牙龈癌发病关系的病例对照研究

Association Between Tea Consumption and Risk of Gingival Carcinoma: A Case-control Study

摘要

摘要:
目的探讨饮茶对牙龈癌发病的影响。
方法采用病例对照的研究方法，病例组为2010年12月—2016年3月经病理确诊的牙龈癌新发病例121例，同期经性别、年龄成组匹配，选取医院体检人群及社区健康人群363例作对照。应用非条件Logistic回归模型计算饮茶及其相关变量与牙龈癌发病风险的调整比值比（OR）及其95％置信区间（CI）并进行相乘交互作用分析。
结果饮茶可降低牙龈癌的发病风险（OR=0.51, 95%CI: 0.29~0.90）；进一步分析发现随着每日饮茶量的增加、饮茶年限的延长，牙龈癌的发病风险也随之降低（均P_trend<0.05）；此外饮茶年龄≥25岁、饮茶浓度适中、饮温茶以及饮绿茶和乌龙茶也可降低牙龈癌的发病风险。分层分析结果发现与吸烟者相比，在非吸烟者中饮茶的保护作用更加显著（OR=0.40, 95%CI: 0.17~0.96），在非饮酒和饮酒者中饮茶的保护作用差异则没有统计学意义。交互作用结果并未发现吸烟与饮茶，饮酒与饮茶之间存在相乘交互作用。
结论饮茶是牙龈癌发病的保护因素，且每日饮茶量、饮茶年限与牙龈癌发病风险之间呈剂量反应关系。

Abstract:
Objective To assess the effect of tea consumption on incidence of gingival carcinoma.
Methods A case-control study including 121 gingival carcinoma patients confirmed by pathological diagnoses and 363 gender-age frequency matched controls were enrolled in Fujian province from December 2010 to March 2016. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to assess the effects of tea related variables on gingival carcinoma and interaction analysis.
Results Tea consumption was associated with decreased risk of gingival carcinoma(OR=0.51, 95%CI: 0.29-0.75). Moreover, with a greater daily quantity and a longer duration of tea-drinking, the risk of gingival carcinoma was reduced (all P_trend<0.05). Furtherly, age of tea drinking initiation (years) more than 25, moderate concentration as well as temperature of tea, drinking green tea and oolong tea were also showed decreased the risk of gingival carcinoma. The stratificated analysis indicated that the protective effect of tea drinking was more evident among non-tobacco smokers(OR=0.40, 95%CI: 0.17-0.96), but no significance was observed in the alcohol drinkers or non-alcohol drinkers. No significantly multiplicative interaction was observed between smoking and tea. The same re sult was found between alcohol drinking and tea.
Conclusion Tea consumption plays a protective effect on gingival carcinoma. Moreover, there is dose-response relationship between daily quantity or duration of tea-drinking and risk of gingival cancer.

HTML全文

参考文献(20)

施引文献

资源附件(0)