TBX3参与恶性肿瘤发生发展的研究进展

Progress of TBX3 in Development of Malignant Tumors

摘要: TBX3（T-box3）基因在人体的正常生长及发育过程中发挥着举足轻重的作用，而TBX3基因在恶性肿瘤呈现过表达的状态，且其过表达与肺癌淋巴结转移及临床分期有着密切关系，下调TBX3基因的表达能够抑制肿瘤细胞的侵袭与转移能力。因此TBX3基因在肿瘤的侵袭及转移过程中起相当重要的作用。本文对TBX3基因结构、TBX3基因促进恶性肿瘤的侵袭转移研究进展予以综述。

Abstract: TBX3 (T-box3) plays an important role in the process of body’s normal growth and development. While TBX3 in tumor is overexpressed, and its overexpression is connected with p-TNM stages and lymphatic metastasis of lung cancer. Downregulating TBX3 expression can suppress the proliferation and invasive abilities of cancer cell line. Therefore, TBX3 plays a quite important role in the invasion and metastasis of tumor. In this paper, we will review TBX3 gene structure, and the research progress of TBX3 promoting tumor cells invasion and metastasis.