Abstract: The malignant degree of high-grade glioma is high. Regular operation plus postoperative radiotherapy and chemotherapy is the standard treatment currently, however, the curative effect has not been obviously improved. Studies have shown that high-grade glioma is radiation resistance, which urgently needs to intensify researches to explore different radiation segmentation model. There are increasing researches on radiotherapy segmentation to improve the prognosis of high-grade glioma patients in recent years. In this review, we discuss the radiation dose fractionation and its influence on the curative effect on high-grade glioma patients.