Abstract: Objective To evaluate the therapeutic value of conservative surgery for malignant ovarian germ cell tumor (MOGCT), to provide scientific evidence for choosing reasonable treatment model on MOGCT patients. Methods We conducted a multi-center, prospective clinical trial. Patients with MOGCT were allocated into conservative surgery group (n=33) and extensive surgery group (n=36). We evaluated the two treatment models by the outcomes of health economics, surgical safety, regular menstruation rate, pregnancy and effectiveness. Results (1) Health economics: the average initial hospital stays of the conservative surgery group and extensive surgery group were 16.27 and 19.91d, respectively; the average initial hospital costs were 16 603.11 and 24 701.58 RMB, respectively (P<0.05). (2) Surgical safety: there were statistical differences between the conservative surgery group and extensive surgery group in the average time of operation, the average recovery time of intestinal tract (P<0.05); there was no significant difference between groups in the average time of pulling out the urine tube (P>0.05); the rates of operative complications were 12.12% (4/33) and 47.22% (17/36) respectively (P<0.05). (3) There were no significant differences between the conservative surgery group and extensive surgery group in the rate of regular menstruation and the pregnancy rates after treatment (P>0.05). (4) Effectiveness: the 3- and 5-year accumulate survival rates of the conservative surgery group were 94% and 87%, while those of the extensive surgery group were both 94%; the 3- and 5-year accumulate progressive-free survival rates of the conservative surgery group were both 92%, while those of the extensive surgery group were both 97% (P>0.05). Conclusion Conservative surgery could reduce the scope of surgery and operative wound, and improve the quality of life without affecting the prognosis of MOGCT patients.