溶血卵磷脂胆碱酰基转移酶1与肿瘤关系的研究进展

Recent Advances of Relationship Between Lysophosphatidylcholine Acyltransferase 1 and Cancer

摘要: 溶血卵磷脂胆碱酰基转移酶1（lysophosphatidylcholine acyltransferase 1, LPCAT1）是一种磷脂酰基代谢酶，可促进磷脂的合成及重构。近年来研究发现LPCAT1在多种肿瘤组织中表达升高，并与肿瘤的恶性程度、分期、分级呈正相关。LPCAT1在肿瘤组织中过表达与前列腺癌、乳腺癌的早期复发呈正相关，在结直肠癌细胞、肝癌细胞中过表达可促进细胞的增殖、迁移、侵袭，是恶性肿瘤早期诊断潜在的生物学标志物和肿瘤治疗的靶点。现对LPCAT1与肿瘤关系的研究进展进行综述。

Abstract: Lysophosphatidylcholine acyltransferase 1(LPCAT1) is a phospholipids metabolic enzyme, which could promote phospholipids synthesis and remodeling. Recent studies found that the expression of LPCAT1 in a variety of tumors is increased and positively correlated with malignancy, staging and grading. High expression of LPCAT1 is positively correlated with the early recurrence of prostate cancer and breast cancer. The over-expression of LPCAT1 could promote the proliferation, migration and invasion of colorectal cancer cells and hematoma cells in vitro. LPCAT1 is a potential biomarker for early diagnosis of malignant tumors and a potential target for the treatment. This article reviews the recent advances of relationship between LPCAT1 and cancer.