转化生长因子-β1 C-509T基因多态性与消化道肿瘤发病风险关系的Meta分析

doi:10.3971/j.issn.1000-8578.2015.12.016

转化生长因子-β1 C-509T基因多态性与消化道肿瘤发病风险关系的Meta分析

Transforming Growth Factor-β1 C-509T Polymorphism and Digestive Tract Cancer Risk: A Meta-analysis

摘要

摘要: 目的探讨转化生长因子-β1（transforming growth factor-β1, TGF-β1）C-509T基因多态性与消化道肿瘤遗传易感性的关联。方法计算机检索PubMed、Embase数据库，检索时间截至2014年12月31日，收集关于TGF-β1基因C-509T位点多态性与消化道肿瘤易感性的病例-对照研究，采用RevMan 5.1和Stata 12.0软件进行Meta分析。结果最终纳入20个病例-对照研究，包括5 230例患者和6 755名对照者。各遗传模型Meta分析结果显示：TGF-β1基因C-509T位点多态性与消化道肿瘤易感性无明显关联。基于人群的亚组分析显示：TGF-β1基因C-509T位点多态性可降低亚洲人群患消化道肿瘤的风险TT/CC: OR=0.74, 95%CI: 0.58~0.95; CT/CC: OR=0.71, 95%CI: 0.54~0.93; TC+CC/TT: OR=0.73, 95%CI:0.56~0.94；T等位基因/C等位基因：OR=0.85, 95%CI: 0.73~0.97，而对高加索人群消化道肿瘤易感性无明显关联。基于癌症种类的亚组分析显示：TGF-β1基因C-509T位点多态性对结直肠癌、胃癌及其他癌易感性无明显关联。结论 TGF-β1基因C-509T位点多态性可减少亚洲人群消化道肿瘤的易感性。

Abstract: Objective To discuss the association between the polymorphism of transforming growth factor- β1(TGF-β1) C-509T and digestive tract cancer risk. Methods We performed a comprehensive search using the databases of PubMed and Embase. The last query was updated on December 31st, 2014. The casecontrol studies of TGF-β1 C-509T polymorphism and the digestive tract cancer susceptibility had been collected. Meta-analysis was conducted using Review Manage version 5.1 and Stata version 12.0 software. Results For TGF-β1 C-509T (20 studies, including 5230 cases and 6755 controls), no significant digestive tract cancer risk was found in the overall analysis. In population subgroup analysis, C-509T polymorphism was associated with decreased digestive tract cancer risk in Asian populationTT/CC:OR=0.74, 95%CI: 0.58-0.95; CT/CC:OR=0.71, 95%CI: 0.54-0.93; TC+CC/TT:OR=0.73, 95%CI: 0.56-0.94; T-allele/C-allele: OR=0.85, 95%CI: 0.73-0.97, but not in Caucasian. In cancer type subgroup analysis, there was no significant risk of colorectal cancer, gastric cancer and other cancers. Conclusion TGF-β1 C-509T polymorphism could decrease the risk of digestive tract cancer in Asian population.

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