Abstract: Although the treatment of gastric cancer is advancing, the clinical outcome is gradually improving, the survival of gastric cancer patients with peritoneal metastasis is still very poor. Effective drugs and strategies against peritoneal metastasis are needed. Now, systemic chemotherapy is the basics, commonly used drugs include S-1, paclitaxel and platinum, etc.. Intraperitoneal chemotherapy with paclitaxel, platinum and docetaxel could also be effective. Cytoreductive surgery combined with intraperitoneal chemotherapy could bring some patients survival benefit, even long-term survival. Peritoneal metastatic lesions showed high levels of epithelial cellular adhesion molecule (EpCAM), an anti-EpCAM monoclonal antibody, Catumaxomab, may be effective against peritoneal metastasis from gastric cancer. In this paper, we review the treatment advances of peritoneal metastasis from gastric cancer.