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栓塞治疗对改善高龄膀胱癌出血患者生活质量的临床意义[J]. 肿瘤防治研究, 2015, 42(04): 378-381. DOI: 10.3971/j.issn.1000-8578.2015.04.013
引用本文: 栓塞治疗对改善高龄膀胱癌出血患者生活质量的临床意义[J]. 肿瘤防治研究, 2015, 42(04): 378-381. DOI: 10.3971/j.issn.1000-8578.2015.04.013
Clinical Significance of Embolization on Quality of Life of Elderly Patients with Bladder Hemorrhage[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 378-381. DOI: 10.3971/j.issn.1000-8578.2015.04.013
Citation: Clinical Significance of Embolization on Quality of Life of Elderly Patients with Bladder Hemorrhage[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 378-381. DOI: 10.3971/j.issn.1000-8578.2015.04.013

栓塞治疗对改善高龄膀胱癌出血患者生活质量的临床意义

Clinical Significance of Embolization on Quality of Life of Elderly Patients with Bladder Hemorrhage

  • 摘要: 目的 评价经导管动脉栓塞术治疗对改善高龄膀胱癌出血患者生活质量的临床意义。方法 回顾性分析23例高龄膀胱癌合并出血患者行栓塞治疗的临床资料,其中19例实施了双侧栓塞、4例实施了单侧栓塞。对栓塞术后造影结果、血尿控制、生活质量、并发症状况进行评估观察。结果 插管造影技术成功率100%,20例患者术后1~5天(平均3天)血尿停止(20/23,87.0%),其余3例再次行栓塞术后出血停止。4例患者分别在术后3、4、4、6月再次出现血尿症状,远期临床成功率为82.6 %。术后7天生活质量较术前明显改善(P<0.001),术后无误栓、膀胱坏死、肾功能损伤等严重并发症。结论 经导管动脉栓塞术治疗高龄膀胱癌出血疗效确切、生活质量明显改善,且创伤小、并发症少, 可作为一种优先选择的临床治疗手段。

     

    Abstract: Objective To evaluate the feasibility, efficacy and complications of transcatheter arterial embolization as a palliative measure for the quality of life(QOL) of elderly patients with bladder hemorrhage. Methods We analyzed retrospectively the clinical data of transarterial embolotherapy on 23 elderly patients with bladder hemorrhage from January 2007 to December 2012, 19 patients underwent bilateral embolization and 4 patients underwent unilateral embolization. Post-embolization angiography findings, bleeding control, QOL and complications were assessed. Results The technical success rate was 100%. Hematuria was controlled after the first procedure(1-5d after embolization) in 20 patients(81.7%) and a repeat procedure was succeeded in the remaining three patients. The forward clinical success was 82.6% since late bleeding recurrence occurred 3, 4, 4 and 6 months after operation was reported in 4 patients during the follow-up. The general QOL was significantly improved compared with the preoperative condition(P<0.001). No major complications related to procedure, such as buttock or perineal pain, bladder necrosis, renal function damage etc., occurred. Conclusion Selective transcatheter arterial embolization is feasible, safe and effective to control refractory bladder bleeding in elderly patients. This procedure should be considered as an alternative less-invasive palliative measure and the treatment of choice.

     

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