Abstract: miRNAs (microRNAs) are short non-coding RNAs that play critical roles in numerous cellular processes through posttranscriptional regulating functions, and participate in the regulation of cell proliferation, metabolism, apoptosis and differentiation. The dysregulation of miRNA expression contributes to tumorigenesis, including multiple myeloma (MM). In this review we summarize the current knowledge on roles of miRNAs in the pathogenesis, diagnosis, treatment and prognosis of MM.