Abstract: Objective To evaluate the association between non-aspirin non-steroidal anti-inflammatory drugs and risk of skin cancer. Methods References about non-aspirin non-steroidal anti-inflammatory drugs and risk of skin cancer were identified in PubMed（Medline）, EMBASE，BIOSIS, Cochrane library and CNKI. Literature screening, quality assessment and data collection were done according to the inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and publication bias were assessed by Stata 10.0. A fixed-effect model was used to combine all original data when there is no statistically significant heterogeneity. Results A total of 12 independent studies from 10 articles consisting of 482 264 skin cancer patients were included in the analysis. The pooled OR was 1.00 and 95%CI was 0.98-1.02. Conclusion No enough evidence could prove non-aspirin non-steroidal anti-inflammatory drugs are significantly related to the risk of skin cancer. Large clinical randomized controlled trials are still needed to confirm the result.