细胞分化与子宫颈癌
Cell Differentiation and Cervical Cancer
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摘要: 分化障碍在子宫颈癌鳞癌发病机制中作用至关重要,本文就上皮细胞分化的进程、特异分子标识、调控程序加以总结;并对ΔNp63α、ITCH、Notch1、miRNA的异常表达在鳞状上皮细胞分化障碍致细胞癌变中的机制加以综述。Abstract: Cell differentiation disorders play an important role in the mechanisms of cervical squamous cancer. This paper is to review differentiation disorders involved in the progress, specifi c molecular markers, and regulatory programs of epithelial, as well as abnormal expression of ΔNp63α, ITCH, Notch1 and miRNA in the malignant transformation.