Abstract: The cancer-testis antigens (CTA) are an expanding family of tumor-associated antigens including MAGE and NY-ESO-1, which have specifi c expression patterns. Because of their ability to elicit autologous cellular immune responses in tumor patients, CTAs have been identified important candidates for cancer immunotherapy. This article reviews the expression of CTAs in breast cancer, especially the expression in the triple negative breast cancer (TNBC) and their clinical signifi cance. This provides the new concept and thinking for immunization strategies in breast cancer. CTA appears an ideal target for TNBC specific immunotherapy.