索拉非尼对中晚期肝细胞癌患者近期生活质量的影响

Improvement of Sorafenib on Recent Quality of Life for Patients with Terminal-stage Hepatocellular Carcinoma

摘要: 目的研究索拉非尼治疗三月后对中晚期肝细胞癌患者生活质量的影响。方法运用EORTC QLQ-C30量表评定36例口服索拉非尼治疗患者的生活质量，分析比较患者治疗前与治疗后3月生活质量的变化。结果患者在躯体功能、疲倦、恶心呕吐、疼痛、便秘、腹泻及经济方面的评分，差异有统计学差异（P<0.05），总体生活质量无明显变化。结论索拉非尼作为分子靶向治疗新药，不仅可延长肝细胞癌患者的生存期，且近期生活质量无明显下降，耐受性较好。

Abstract: Objective To explore the improvement of sorafenib treatment on the recent quality of life for patients with terminal-stage hepatocellular carcinoma after three months. Methods We investigated the quality of life of 36 patients with oral sorafenib by the Quality of Life Questionnaire-C30(QLQ-C30) V3.0 of EORTC. The quality of life before and 3 months after the treatment was analyzed. Results There were signifi cant difference among physical status, fatigue, nausea and vomiting, pain, constipation, diarrhea and economic diffi culties(P<0.05) but the overall quality of life had no obvious improvement.