Abstract: Objective To analyze the effectiveness of ventriculoperitoneal shunt and Ommaya reservoir placement in the treatment of Leptomeningeal Metastases (LM) from pulmonary adenocarcinoma on the basis of radiotherapy and chemotherapy. Methods The clinical and follow-up data of 39 patients who were diagnosed with LM from pulmonary adenocarcinoma was retrospectively reviewed. They were divided into 3 groups according to the different treatment methods, the group with ventriculoperitoneal shunt (VP shunt) and Ommaya reservoir placement, the group with Ommaya reservoir placement only and the group without operation. Survival was analyzed using Kaplan-Meier methodology and shown as survival curve. Logrank test was used to evaluate the differences among the groups. Results The median survival time of the entire group was 5.1 months (range: 0.6-26 months). Survival rate of one year was 12.8% (5/39). Karnofsky performance scale scores were significantly improved with a score of 18.2 after VP shut placement. The median survival time of the group with ventriculoperitoneal shunt (VP shunt) and Ommaya reservoir placement was 7.8 months, while only 3.2 months in the group without operation( χ²=4.927, P=0.026). Conclusion LM from pulmonary adenocarcinoma is correlated with poor prognosis. In this study, the quality and time of life are improved by the application of VP shunt and Ommaya reservoir placement. But clinical research and verifi cation of large sample and multi-center cooperation are still needed.