Abstract: Objective To investigate the relationship between expression of receptor of hyaluronic acid mediated motility (CD168) in gastric carcinoma tissue and clinicopathologic factors and prognosis,and we evaluated the role of CD168 in gastric carcinoma invasion and metastasis and the significance of predicting prognosis in gastric carcinoma patients was evaluated. Methods We examined the CD168 expression of 72 gastric carcinoma tissue and 26 normal gastric mucosa by immunohistochemical method.We also evaluated the correlation between CD168 expression and clinicopathological factors (age,gender,histology,tumor depth,lymph node status,and clinical stages).We assessed the postoperative five-year survival rate of gastric carcinoma patients by Kaplan-Meier method. Results CD168 expression was detectable in 42 of the 72 tumors (58.3%) and 5 of 26 in normal gastric mucosa (19.2%),and there was significant difference on their positive expression rates(P=0.001)；CD168 positive expression rate was significantly correlated with the differentiated degree(P=0.001),lymph node metastasis(P=0.003),and clinical stages (P=0.020).There was no significant difference between positive expression rate of CD168 and age gender tumor size and depth of invasion.Survival analysis of gastric carcinoma patients showed that the CD168-negative group(67.2%) had a significantly higher five-year survival rate than the CD168-positive group (29.8%), significantly(P=0.01). Conclusion Our findings suggest that CD168 is strongly related to the invasion and metastasis of gastric carcinoma.These results suggest that CD168 expression could be used as a prognostic biomarker of gastric carcinoma.