Abstract: ObjectiveTo evaluate the effects of Chinese criteria of clinical staging system for esophageal cancer in the treatment of non-surgical esophageal cancer,and investigate the other factors influenced on prognosis of non-surgical esophageal cancer. Methods All with esophageal squamous cell cancer retrospectively 542 patients were divided into different stages according to the Chinese criteria of clinical staging system for esophageal cancer.OS was analyzed by Kaplan-Meier curves. Results Among the 542 cases,the 1-,3-,5-year survival rates were 86.8%,63.2% and 47.3%,respectively.Significant differences(P=0.000)were shown in different TNM stages.Upper esophageal disease had better prognosis than middle and lower disease(P=0.000 and 0.004).Pathology differentiations were also a factor impacted on the prognosis (P=0.019). Conclusion The Chinese criteria of clinical staging system for esophageal cancer were adaptable to predict prognosis of esophageal squamous cell cancer treated by non-surgical therapy.Anatomic site and Pathology differentiation should also be considered in the staging system.