新疆哈萨克族食管鳞癌中HLA-G的表达及临床意义

Expression and Significance of HLA-G in Kazak Patients with Esophageal Squamous Cell Carcinoma

摘要: 目的探讨人类白细胞抗原-G(human leucocyte antigen,HLA-G)在新疆哈萨克族食管鳞癌中的表达及临床意义。方法应用免疫组织化学SP 法对30例哈族食管鳞癌及20例癌旁正常组织中HLA-G 的表达进行检测。结果哈族食管鳞癌组织中HLA-G的表达率为66.7%，明显高于癌旁正常组织20.0%，差异具有统计学意义(P＜0.05)；HLA-G的表达与哈族食管癌浸润深度和临床分期关系密切(P均<0.05)，而与患者年龄、性别、食管癌发生部位、分化程度和淋巴结转移无明显相关性(P均>0.05)。结论HLA-G的高表达可能在新疆哈族食管鳞癌的发生发展中起重要作用。

Abstract: Objective To investigate the expression and clinical significance of HLA-G in Xinjiang Kazak patients with esophageal squamous cell carcinoma(ESCC). Methods The expression of HLA-G was detected using SP immunohistochemical staining in 30 ESCC and 20 cases of tumor adjacent normal tissues. Results The positive rate of HLA-G expression in ESCC was 66.7%(20/30),significantly higher than that in tumor adjacent normal tissues(20%)(P＜0.05).The positive rate of HLA-G was closely related with depth of invasion and clinical stage(P＜0.05 for all),but not with age,gender,tumor location,histologic grade and lymphnode metastasis(P＞0.05 for all). Conclusion The significantly over expression of HLA-G might play a key role in the pathogenesis of Kazak ESCC in Kazak population.