男性乳腺癌的临床病理特征与预后的相关性分析—40例临床资料总结

doi:10.3971/j.issn.1000-8578.2012.12.013

男性乳腺癌的临床病理特征与预后的相关性分析—40例临床资料总结

Analysis of Clinical Features and Prognostic Factors of Male Breast Cancer:A Review of 40 Cases

摘要

摘要: 目的探讨影响男性乳腺癌患者预后的因素。方法回顾性总结1990年1月—2011年5月在广西医科大学第一附属医院收治的40例男性乳腺癌患者的临床资料。采用Kaplan-Meier法、Cox比例风险回归模型和Log rank 检验分析影响男性乳腺癌患者预后的因素。结果本组全部40例男性乳腺癌患者均随访，5年总生存率为67.5%。单因素分析显示，患者的预后与肿瘤大小、腋窝淋巴结转移、ER和PR、TNM 分期、手术方式、有无内分泌治疗等因素有关（P<0.05）。多因素分析显示，TNM 分期、有无手术和有无内分泌治疗是影响预后的重要因素。结论早期诊断和以手术为主、辅以内分泌治疗的综合治疗能够提高男性乳腺癌患者生存率。

Abstract: Objective To investigate the prognostic factors in patients with male breast cancer(MBC). Methods A total of 40 patients with MBC treated in the First Affiliated Hospital of Guangxi Medical University between January,1990 and May,2011 were analyzed retrospectively.Kaplan-Meier,Log rank test and Cox regression model were used to analyze the prognostic variables. Results The follow-up rate was 100%.The total 5-year overall survival was 67.5%.Univariate analysis indicated that the tumor size,axillary lymph node status,ER and PR status,TNM stage,operation model and endocrine therapy were significant predictors of survival.Multivariate analysis showed that TNM stage,operation model and endocrine therapy were independent prognostic factors. Conclusion Early diagnosis and comprehensive treatment consisting of operation and endocrine therapy can significantly improve the survival of MBC.

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