Abstract: Objective To investigate the efficacy and feasibility of continuous intravenous morphine pumping in patients with refractory cancer pain. Methods A total of 84 patients with refractory cancer pain underwent continuous intravenous morphine pumping from April 2010 to Aug,2011.And to evaluate the time of beginning pain relief,pain intensity,the degree of pain relief and its adverse reaction.And to compare the numerical rating scale(NRS) before and after treatment. Results The average time of beginning of pain relief was 32 min.The NRS before and after treatment were 7.57 and 1.87 respectively(P<0.001)．The degree of pain relief was 91.7%.The main adverse reaction was constipation,nausea,vomiting and urine retention. Conclusion Continuous intravenous morphine pumping is effective,safe and feasible in the treatment of refractory cancer pain.