Abstract: Objective To probe the curative effect of malignant melanoma on skin treated by surgical method combined immunotherapy. Methods From August 1998 to June 2011，34 patients with malignant melanoma on skin were treated in our department.A focus was excised totally on a certain depth and width using non-tumor technique，then according to the site，area and depth of wound and the principle of “rather near than further，rather simple than complicated”，a flap or skin graft was employed to repair the wound.Then according to the theory “strengthening the body resistance to eliminate pathogenic factors”，immunotherapy was selected as an accessory treatment after operation，and follow-up was carried out on schedule. Results Of fourteen cases repaired by 18 skin flaps，all of skin flaps survived，and the appearance and function of operative areas were good.Among them，13 patients were followed up from seven months to eleven years after operation.Nine patients survived and four died，and in the survivors，one case already survived eleven years without tumor.Of eighteen cases repaired with skin grafts，the survival rate of skin graft was about 95% in seven cases，the wounds healed by dressing change.In the other cases，the survival rate of skin grafts reached 100%，and satisfactory appearance and function of operative areas appeared.In those patients，fifteen patients were followed up from one year to ten years after operation，and the results showed nine patients survived and six died.Two cases were carried out metacarpophalangeal or metatarsophalangeal joint amputation respectively，the incision healed on the first stage.Now they were in fifteen months and two years after operation，general condition was very well，and no any local recurrence was appeared. Conclusion It might be a good method to treat malignant melanoma on skin with surgical method combined immunotherapy at present.