Abstract: Objective To investigate the clinicopathological features and key points of different diagnosis of Adenomatoid Tumors(ATs）of the uterus. Methods The clinical，histopathological and immunohistochemical features were evaluated in 11 cases of ATs retrospectively. Results Most patients were women of child-bearing period，the disease was often accompanied by uterine smooth muscle tumors (36.7%).A variety of microscopic patterns of tumor including signet ring-like cells，crack-like cavities，polycystic reticular structure and irregular large cystic structure were presented.Immunohistochemical staining showed strong positive for panCK(100%），calretinin(100%） and HBME-1(82%），weak positive for CK5/6(27.3%），but negative for CD31(0）.The main different diagnosis was adenocarcinoma and leiomyoma. Conclusion Careful dissection，accurately grasping of microscopic morphology，key points of different diagnosis and immunohistochemistry techniques are useful in establishing a correct diagnosis of ATs，and avoiding misdiagnosis and mistherapy of clinical managment.