Trx-1和COX-2在非小细胞肺癌中的表达及意义
Expression of COX-2 and Trx-1 in Non-small Cell Lung Cancer
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摘要: 目的 探讨硫氧化还原蛋白1(thioredoxin，Trx-1)和COX-2在非小细胞肺癌中的表达及其临床意义。方法免疫组织化学方法检测63例非小细胞肺癌组织和20例癌旁正常肺组织中Trx-1和COX-2的表达。结果63例非小细胞肺癌组织中Trx-1和COX-2均呈高表达，分别为63.5%（40/63）和59.1%（37/63），20例正常肺组织Trx-1阳性3例，COX-2阳性2例，差异具有统计学意义(P<0.05)。Trx-1在低分化癌组织中阳性表达率高于中高分化癌组织，差异具有统计学意义(P<0.05)；在不同TNM分期的非小细胞肺癌组织中，阳性表达率差异具有统计学意义(P< 0.05)，在有淋巴结转移的癌组织中阳性表达率高于无淋巴结转移者，差异具有统计学意义(P<0.05)。COX-2的表达与TNM分期及淋巴结转移差异具有统计学意义(P<0.05)。结论Trx-1和COX-2的表达与非小细胞肺癌患者预后密切相关。Abstract: Objective To investigate the expressions of thioredoxin 1(Trx-1) and COX-2 in 63 cases with non-small cell lung cancer. Methods The expressions of Trx-1 and COX-2 were detected in 63 cases non-small cell lung cancer tissues and 20 cases adjacent normal lung tissues by means of immunohistochemical method. Results The positive rates of Trx1 and COX-2 in non-small cell lung cancer tissues were 63.5% and 59.1% respectively，and higher than those in adjacent normal lung tissues(P<0.05).In 20 cases of non-malignant tissue sections，Trx1 and COX-2 expression was observed in 3 and 2 cases，respectively.Trx1 was related to the degree of differentiation.The positive rate of Trx1 in low degree of differentiation was higher than that in high degree(P<0.05).The expression difference of Trx1 between the patients with and without lymph nodes metastasis was also significant(P<0.05).Tumor lymph node metastasis and TNM stage correlated with the expression of COX-2(P<0.05). Conclusion The expression of Trx-1 and COX-2 were closely related to prognosis of non-small cell lung cancer.
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