Abstract: ObjectiveTo evaluate the clinical efficacy and the progression-free survival（PFS） of maintenance therapy with Traditional Chinese Medicine Hechanpian in patients with intermidiate and advanced non-small cell lung cancer. Methods Seventy-eight cases of NSCLC in Ⅲ/Ⅳ stage after initial therapy 44 cases were randomly divided into treatment group and 34 cases control group.The 44 patients in the treatment group received Hechanpian and the other 34 patients in the control group received continual observation.Progression-free survival was used to analyze the quality of life and to observe the impact on each patient. Results There are 77 patients included in the trial and 1 patient excluded.Baseline characters between groups has not achieved statistically difference (P>0.05).Median PFS of the treatment group and control group are 5.67 month and 4.12 month, respectively. The two groups have significant difference ( P=0.048), The quality of life between two groups also has statistically different(P<0.05). Conclusion Maintenance treatment with Hechanpian is safe and feasible，it can prolong the PFS and improve symptom patients with intermidiate and advanced non-small cell lung cancer, and show a favorable toxicity profile.