Abstract: ObjectiveTo observe the complications after Argon-Helium cryosurgery on advanced lung cancer, and research on strategy of the prevention and treatment. MethodsOne hundred and twenty cases of lung cancer patients were treated with cryosurgery. We observed the complications, summarized prevention and therapy methods. ResultsAll patients underwent the treatment successfully without dead cases. The main complications are :fever, hemoptysis, pneumatothorax, hydrothorax,low temperature, tumor lysis syndrome. ConclusionThe cryosurgery is an effective method with mild complications that could recover soon after corresponding therapy. It could significantly improve the quality of life of the lung cancer patients.