Abstract: ObjectiveTo analyz the clinical efficacy and toxicity of fluorouracil sustained-release implant and interstitial-implant radiotherapy on younger women of massive cervical carcinoma. Methods Twenty samples withⅠB2~ⅡA cervical squamous cell carcinoma from April 2009 to January 2010 were randomly divided into two groups by different therapy:one group with fluorouracil sustained-release implant (ten cases)and the other group with interstitial-implant radiotherapy (ten cases). Monitoring the extent of the local tumor subsiding and detecting the toxicity and the follow-up ovarian hormone levels in three months. Results With treatment of three weeks,the average effective rate (tumor reduced) of the two groups were 70% and 80%, respectively. There was no significant difference（P>0.05）. However, interstitial-implant radiotherapy samples showed ovarian dysfunction induced FSH and LH increasing, While E2 decreasing（P<0.05）. Comparing the two groups in terms of surgery time，amount of bleeding，intraoperative complications and early postoperative complications，there was no significant difference（P>0.05）. Conclusion Fluorouracil sustained-release implant has a direct and effective anti-tumor effect in the treatment of Massive Cervical Carcinoma. It can also protect ovarian function on younger women of cervical carcinoma.