PDGF-D及其受体在胃癌组织中的表达及意义

doi:10.3971/j.issn.1000-8578.2011.02.013

PDGF-D及其受体在胃癌组织中的表达及意义

Expression and Significance of PDGF-D and Its Receptor in Gastric Carcinoma Tissues

摘要

摘要: 目的探讨血小板衍生生长因子-D（PDGF-D）及其受体PDGFRβmRNA在胃癌组织中的表达及其与临床病理特征的关系。方法用RT-PCR方法检测58例胃癌及相对应的癌旁标本中PDGF-D及PDGFRβ mRNA的表达，分析其与临床病理特征的关系。结果PDGF-D及PDGFRβ在胃癌组织中的阳性表达率（98.28%，72.41%）均高于癌旁组织（87.93%，53.45%），P均＜0.05。PDGFRβ与PDGF-D的表达呈正相关（r=0.40，P＜0.05）。PDGF-D mRNA的表达水平与胃癌的淋巴结及远处转移和复发有关（P＜0.05），与其他临床病理特征无关（P＞0.05）。结论PDGF-D在胃癌的发生、发展和转移、复发中可能起着重要的作用，可作为预测胃癌转移和复发的有意义指标。

Abstract: ObjectiveTo investigate the correlation between mRNA expression of PDGF-D and PDGFRβ and clinicopathological features in gastric cancer. Methods The reverse transcription-polymerase chain reaction（RT-PCR）technique was used to examine mRNA expression of PDGF-D and PDGFRβ in 58 paired specimens of gastric carcinoma and tissues adjacent carcinoma. Results The positive rates of PDGF-D mRNA and PDGFRβ mRNA（98.28%，87.93%）were higher in gastric cancer tissues than（72.41%,53.45%）in tissues adjacent carcinoma respectively. While the positive rate of PDGFRβmRNA was 72.41%,which was positively correlated with PDGF-D（r=0.40，P＜0.05）.PDGF-D expression was correlated with lymph node metastasis and relapse (P＜0.05).No correlation was found between PDGF-D and other clinicopathological features of gastric carcinoma(P＞0.05). Conclusion PDGF-D may play a crucial role in carcinogenesis,development，metastasis and relapse of gastric cancer. It can be used as prognostic markers of gastric cancer in clinical practice.

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